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2 "Hyo Jin Lee"
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Original Articles
Neurology
The effects of hypomagnesemia on delirium in middle-aged and older adult patients admitted to medical intensive care units
Joong-Yub Kim, Hyo Jin Lee, Hong Yeul Lee, Sang-Min Lee, Jinwoo Lee, Tae Yun Park
Acute Crit Care. 2022;37(3):407-414.   Published online July 5, 2022
DOI: https://doi.org/10.4266/acc.2022.00164
  • 3,617 View
  • 197 Download
  • 2 Web of Science
  • 1 Crossref
AbstractAbstract PDF
Background
In critically ill patients, the most common manifestation of brain dysfunction is delirium, which is independently associated with higher morbidity and mortality. While electrolyte imbalance is one of the precipitating factors, the impact of hypomagnesemia on the incidence of delirium remains unknown.
Methods
We retrospectively analyzed patients admitted to the medical intensive care unit (ICU) of a tertiary referral center between January and June 2020. Patients with ICU stay ≥48 hours and aged 40–85 years were included. The primary outcome was cumulative incidence of delirium in the ICU. Patients were divided into two groups based on serum magnesium level at ICU admission. Multivariable Cox proportional hazards regression analysis was performed, and covariates were selected using the least absolute shrinkage and selection operator (LASSO) method.
Results
A total of 109 patients included 43 (39.4%) women and had a median age of 69.0 years (interquartile range [IQR], 60.0–76.0 years). The median magnesium level was 1.7 mg/dl (IQR, 1.5–1.9 mg/dl), and the cumulative incidence of delirium was 32.1% (35 patients). Hypomagnesemia was independently associated with delirium (adjusted hazard ratio [aHR], 2.12; 95% confidence interval [CI], 1.03–4.38), along with prior use of immunosuppressants (aHR, 3.08; 95% CI, 1.46–6.48) or benzodiazepines (aHR, 4.02; 95% CI, 1.54–10.50), body mass index (aHR, 0.93; 95% CI, 0.84–1.02), and alcohol history (aHR, 1.68; 95% CI, 0.74–3.80).
Conclusions
In critically ill adults, hypomagnesemia increases the risk of delirium by more than two-fold compared to patients with normal magnesium level.

Citations

Citations to this article as recorded by  
  • Hypomagnesemia and incident delirium in hospitalized older persons
    Virginia Boccardi, Sara Ercolani, Rocco Serra, Valentina Bubba, Alessandro Piccolo, Michela Scamosci, Alfredo Villa, Carmelinda Ruggiero, Patrizia Mecocci
    Aging Clinical and Experimental Research.2023; 35(4): 847.     CrossRef
Neurology
Association of natural light exposure and delirium according to the presence or absence of windows in the intensive care unit
Hyo Jin Lee, Eunhye Bae, Hong Yeul Lee, Sang-Min Lee, Jinwoo Lee
Acute Crit Care. 2021;36(4):332-341.   Published online November 26, 2021
DOI: https://doi.org/10.4266/acc.2021.00556
  • 6,195 View
  • 207 Download
  • 9 Web of Science
  • 11 Crossref
AbstractAbstract PDFSupplementary Material
Background
Patients in the intensive care unit (ICU) have increased risks of delirium, which is associated with worse outcomes. As pharmacologic treatments for delirium are ineffective, prevention is important. Nonpharmacologic preventive strategies include exposure to natural light and restoring circadian rhythm. We investigated the effect of exposure to natural light through windows on delirium in the ICU.
Methods
This retrospective cohort study assessed all patients admitted to the medical ICU of a university-affiliated hospital between January and June 2020 for eligibility. The ICU included 12 isolation rooms, six with and six without windows. Patients with ICU stays of >48 hours were included and were divided into groups based on their admission to a single room with (window group) or without windows (windowless group). The primary outcome was the cumulative incidence of delirium. The secondary outcomes were the numbers of delirium- and mechanical ventilation-free days, ICU and hospital length of stay, and in-ICU and 28-day mortalities.
Results
Of the 150 included patients (window group: 83 [55.3%]; windowless group: 67 [44.7%]), the cumulative incidence of delirium was significantly lower in the window group than in the windowless group (21.7% vs. 43.3%; relative risk, 1.996; 95% confidence interval [CI], 1.220–3.265). Other secondary outcomes did not differ between groups. Admission to a room with a window was independently associated with a decreased risk of delirium (adjusted odds ratio, 0.318; 95% CI, 0.125–0.805).
Conclusions
Exposure to natural light through windows was associated with a lower incidence of delirium in the ICU.

Citations

Citations to this article as recorded by  
  • Geriatric Psychiatric Emergencies
    Michelle A. Fischer, Monica Corsetti
    Emergency Medicine Clinics of North America.2024; 42(1): 135.     CrossRef
  • There’s No Place Like Home: Delirium as a Barrier in Geriatric Trauma
    Abdoulaziz Toure, Roshan Tadi, Mitchell Meagher, Catherine Ting Brown, Hoi Lam, Samantha LaRosa, Launick Saint-Fort, Huda Syed, Nathaniel Harshaw, Katherine Moore, Neelofer Sohail, Lindsey L. Perea
    Journal of Surgical Research.2024; 293: 89.     CrossRef
  • The Influence of Exposure to Nature on Inpatient Hospital Stays: A Scoping Review
    Keegan Guidolin, Flora Jung, Sarah Hunter, Han Yan, Marina Englesakis, Stephen Verderber, Sami Chadi, Fayez Quereshy
    HERD: Health Environments Research & Design Journal.2024;[Epub]     CrossRef
  • ICU design analysis: Are we really moving forward?
    M Harazim
    Anesteziologie a intenzivní medicína.2024; 35(1): 8.     CrossRef
  • Four Decades of Intensive Care Unit Design Evolution and Thoughts for the Future
    Neil A. Halpern, Elizabeth Scruth, Michelle Rausen, Diana Anderson
    Critical Care Clinics.2023; 39(3): 577.     CrossRef
  • Improving healthcare value: integrating medical practitioners into hospital design in developing countries
    Carlos Machhour Noujeim
    Healthcare in Low-resource Settings.2023;[Epub]     CrossRef
  • Evaluation of the sensory environment in a large tertiary ICU
    Oystein Tronstad, Dylan Flaws, Sue Patterson, Robert Holdsworth, Veronica Garcia-Hansen, Francisca Rodriguez Leonard, Ruth Ong, Stephanie Yerkovich, John F. Fraser
    Critical Care.2023;[Epub]     CrossRef
  • 2021 KSCCM clinical practice guidelines for pain, agitation, delirium, immobility, and sleep disturbance in the intensive care unit
    Yijun Seo, Hak-Jae Lee, Eun Jin Ha, Tae Sun Ha
    Acute and Critical Care.2022; 37(1): 1.     CrossRef
  • Post-acute delirium of COVID-19 infection: Report of two cases
    Dai-Chun Chi, Chih-Pang Chu, TienWei Yang, Hu-Ming Chang
    Taiwanese Journal of Psychiatry.2022; 36(1): 44.     CrossRef
  • The future of intensive care: delirium should no longer be an issue
    Katarzyna Kotfis, Irene van Diem-Zaal, Shawniqua Williams Roberson, Marek Sietnicki, Mark van den Boogaard, Yahya Shehabi, E. Wesley Ely
    Critical Care.2022;[Epub]     CrossRef
  • The effects of hypomagnesemia on delirium in middle-aged and older adult patients admitted to medical intensive care units
    Joong-Yub Kim, Hyo Jin Lee, Hong Yeul Lee, Sang-Min Lee, Jinwoo Lee, Tae Yun Park
    Acute and Critical Care.2022; 37(3): 407.     CrossRef
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